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Abstract

Flatfoot deformities are a prevalent condition characterized by the loss of medial longitudinal arch height in the foot. This review explores the interplay between genetic predispositions and environmental factors in the development of flatfoot deformities. Genetic studies have identified potential candidate genes involved in foot structure and biomechanics, suggesting a hereditary component to flatfoot pathogenesis. However, environmental influences such as footwear choices, physical activity levels, and biomechanical stressors also play crucial roles. Understanding the complex interactions between genetics and environment is essential for developing effective prevention strategies and personalized treatment approaches for individuals predisposed to or affected by flatfoot deformities. This paper synthesizes current knowledge and highlights areas for future research to better elucidate the multifactorial nature of flatfoot development.