Ghrelin and Resistin Status in Women with Metabolic Syndrome
*Corresponding Author:Received Date: Dec 01, 2023 / Published Date: Dec 30, 2023
Copyright: © 2024 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Background/Aims: This is a comparative study that aims to evaluate serum levels of ghrelin, resistin, insulin and identify possible correlations that may exist between these parameters in a population of an obese diabetic woman with metabolic syndrome and to assess their spontaneous alimentation. Methods: Measurement of ghrelin, resistin, glucose, insulin and lipid profile were performed in 53 obese diabetic women with metabolic syndrome and 52 healthy women subjects. A food survey was conducted in the study. Results: Our data show a significant difference in levels of ghrelin and resistin between the two groups. In fact, ghrelin level in obese diabetics is (25.46 ± 3.59 pg / ml) against (50.66 ± 6.84 pg / ml) for the control and resistin rate is (9.17 ± 1.68 ng / ml) against (3.17 ± 0.51 ng / ml) for the control group. A significant negative correlation was revealed between ghrelin and glucose (p = 0.003), ghrelin and insulin (p = 0.002) and ghrelin and resistin (p = 0.001). In addition, a significant positive correlation was found between resistin and BMI (p <0.001) likewise resistin and insulin (p<0.001). Our food survey showed a significant difference in nutrient intake between the two groups of the study (p<0.001). Conclusions: The present study revealed the relation of resistin and ghrelin to obesity associated with diabetes and metabolic syndrome, and the impact of diet on lipid parameters and metabolic profile
