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Abstract

This study investigates the effects of ghrelin on the bursa of Fabricius and cecal tonsils in chickens infected with an attenuated strain of the infectious bursal disease virus (IBDV). A total of 60 chickens were divided into two groups: one receiving ghrelin treatment and the other serving as a control. Following infection with the attenuated IBDV strain, tissue samples from the bursa and cecal tonsils were collected at multiple time points for histopathological examination and immunohistochemical analysis. Results indicated that ghrelin treatment significantly mitigated the inflammatory response in both the bursa and cecal tonsils, as evidenced by reduced lymphocytic infiltration and tissue damage compared to the control group. Furthermore, ghrelin was associated with enhanced expression of immune-related markers, suggesting a potential immunomodulatory role. These findings highlight the therapeutic potential of ghrelin in managing IBDV infections, pointing to its ability to protect immune organs and enhance overall immune function in chickens. Future studies should explore the underlying mechanisms of ghrelin's effects and its potential applications in poultry health management.