Hard outcomes in Critically Ill Patients with ARDS Caused by SARS-CoV-2 Infection: A Retrospective Group Study
*Corresponding Author: Gabriela Maria Mora Martinez, Department of Intensive Care, Central South High Specialty Hospital, Mexico City, Mexico, Email: gabriela.mora.mtz@hotmail.comReceived Date: Nov 25, 2024 / Published Date: Dec 26, 2024
Citation: Martinez GMM, Hernandez TAT, Palacios PV, Correa JGE, Gutierrez AER (2024) Hard outcomes in Critically Ill Patients with ARDS Caused by SARS-CoV-2 Infection: A Retrospective Group Study. J Infect Dis Ther S4:001.DOI: 10.4172/2332-0877.24.S4.001
Copyright: © 2024 Martinez Mora Maria G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credite
| Peer-reviewed Full Article 
Abstract
Background: The Coronavirus Disease (COVID-19) pandemic has exerted immense pressure on healthcare systems, particularly in the management of patients with Acute Respiratory Distress Syndrome (ARDS). Identifying predictors of survival in critically ill patients is essential for optimizing treatment strategies.
Materials and Methods: A retrospective study was conducted in an Intensive Care Unit (ICU) in Mexico City, spanning from March, 2020 to March, 2023. The study included patients aged 18 years and older with confirmed COVID-19 who required invasive mechanical ventilation. Logistic regression and Kaplan-Meier analyses were performed to evaluate factors associated with mortality.
Results: A total of 157 patients were included, with a mean age of 62.8 years and 74.5% were male. The 90 days survival rate was 41.4%, with a mortality rate of 58.6%. Acute kidney injury (AKI) (OR=3.4), hemodynamic failure (OR=6.5) and elevated lactate levels (OR=0.201) were significantly associated with increased mortality risk. Kaplan-Meier analysis demonstrated significantly reduced survival among patients with AKI, hemodynamic failure and hyperlactatemia.
Discussion: AKI, hemodynamic instability and hyperlactatemia emerged as pivotal predictors of mortality. The high incidence of AKI and associated adverse outcomes highlight the urgent need for management strategies in this vulnerable patient.
Conclusion: The 90 days survival rate was 41.4%. AKI, hemodynamic failure and elevated lactate levels were independently associated with increased mortality, highlighting the necessity for focused and strategic interventions.
