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Abstract

Corneal neuropathic pain is a debilitating condition characterized by persistent ocular discomfort, burning, and stinging sensations, often resulting from damage or dysfunction of corneal nerves. This condition poses significant challenges in ophthalmology and pain management, impacting patient quality of life. Understanding the neurophysiological mechanisms underlying corneal neuropathic pain is crucial for the development of effective treatments. This abstract provides insights into the pathophysiological mechanisms implicated in corneal neuropathic pain, including nerve injury, sensitization, neuroinflammation, and corneal epithelial dysfunction. Emerging therapeutic approaches targeting these mechanisms offer hope for improved pain management and patient outcomes in corneal neuropathy.