Research Article
Magnitude of the Difference between Fasting and Non-fasting Triglycerides, and Its Dependent Factors
Shuman Yang1, Min Liu2 and Tianying Wu1*1Department of Environmental Health, Division of Epidemiology and Biostatistics, University of Cincinnati Medical Center, Cincinnati, Ohio, USA
2Department of Pathology of Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio, USA
- *Corresponding Author:
- Tianying Wu
Division of Epidemiology and Biostatistics
Department of Environmental Health, University of Cincinnati Medical Center
Kettering Complex, 3223 Eden Ave,Cincinnati, Ohio, USA, 45267-0056
Tel: 1-513-556-6229
E-mail: tianying.wu@uc.edu
Received date: September 30, 2015 Accepted date: October 23, 2015 Published date: October 26, 2015
Citation: Yang S, Liu M, Wu T (2015) Magnitude of the Difference between Fasting and Non-fasting Triglycerides, and Its Dependent Factors Running Title: Fasting and Non-fasting Triglycerides. J Community Med Health Educ 5:375. doi:10.4172/2161-0711.1000375
Copyright: © 2015 Yang S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
Abstract
Background: It is largely unknown about the magnitude of the difference between fasting and non-fasting triglycerides, and whether this difference is dependent on certain potential cardiovascular disease (CVD) risk factors.
Methods: We conducted a cross-sectional study of 8,073 participants from the National Health and Nutrition Examination Survey, 2005-2010. Fasting status was classified into two groups: fasting (≥8 hours) and non-fasting status (<8 hours). The difference between fasting and non-fasting triglycerides its dependent CVD risk factors were estimated with linear regression model.
Results: Overall, fasting participants had lower triglycerides than non-fasting participants after adjusting for covariates (difference=4.22 mg/dL; P=0.049). Triglycerides levels at fasting status was interacted with hypertension (P=0.05), antihyperlipidemic agent use (P=0.07) and LDL cholesterol (P=0.04). In the separate analyses of the participants with and without hypertension, antihyperlipidemic agent use, or with high and low levels of LDL cholesterol, fasting triglycerides were much lower than non-fasting triglycerides only in participants with hypertension (difference=14.24 mg/dL; P=0.03), antihyperlipidemic agent use (difference=14.10 mg/dL; P=0.02), or LDL cholesterol <130 mg/dL (difference=6.46 mg/dL; P=0.02).
Conclusions: The difference between fasting and non-fasting triglycerides was 4 mg/dL in the overall samples, and factors that determine the magnitude of differences were hypertension status, antihyperlipidemic agent use and LDL cholesterol levels. These findings may help us to use fasting and non-fasting triglycerides properly to assess the risk of CVDs.
