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Abstract

Overweight and obesity have skyrocketed worldwide over the past three decades at an alarming rate. Lowgrade inflammation, oxidative stress, glucose intolerance, metabolic syndrome, and other metabolic abnormalities are all caused by obesity. Alterations in the energetic metabolism homeostasis and persistent systematic low-grade inflammation have been observed in an identical scenario as aging progresses. Poor physical performance and oxidative stress can raise metabolic disease risk. Despite the many different studies that have been done on the pathophysiological effects of obesity, not enough research has been done on its effects on gender and over time, especially as people get older. The monosodium glutamate (MSG)-induced obese model is the focus of this review, which aims to outline the pathophysiological mechanisms and metabolic changes associated with obesity. Male mice showed more signs of MSG-induced obesity, inflammation, and decreased adiponectin, while both male and female mice's glucose tolerance, insulin sensitivity, and redox balance changed with age. According to these findings, MSGinduced obesity-related metabolic alterations are gender and age related. As a result, the relationship between gender, aging, and metabolic changes in obesity can be supported by the MSG obesity model. We also looked at the medicinal plants and their active ingredients that have been used to treat obesity caused by MSG. Studies are required to investigate the beneficial effects and underlying mechanisms of medicinal plants with demonstrated anti-obesity activity due to this model's significance.