NAFLD the coming global epidemic and health crisis Egypt on the map
Abstract
The ancient Egyptians were black Africans, displaced
by later movements of peoples, for example the Macedonian,
Roman and Arab. Arab invasion, do not seem to
account more than15% of modern Egyptians. Because
the epidemiology and demographic characteristics of NAFLD
vary worldwide, we aimed to identify the risk factors
of NAFLD among Egyptians. We had conducted a lot of
researches regarding genetic polymorphism of the following:
TNF-∂ G238A, PNPLA3, PPAR-gamma, Resistein
& Adiponectin receptors gene liver expression. Also we
had worked on insulin resistance in non-diabetic patients
with NAFLD, Total lipid profile, conjugated linolenic
acid (omega 6), and intestinal microbiota. Our results
showed that; Egyptian with different grads of NAFLD
identified by NAS score in liver biopsy had significant
TNF-∂ G238A, PNPLA3 polymorphism, and Resistein
receptors gene liver expression in NASH patients. In
Egypt a high BMI and insulin resistance level in non-diabetic
patients with NAFLD, and NASH even highest
worldwide. Triglycerides was significantly high, HDL-c
was low in NASH patients, and we had low level of conjugated
linolenic acid in NAFLD patients getting more
worse with the severity of the disease. CD163, and LPS
were significantly higher in patients with NASH prove
the relation of intestinal dyspiosis and NASH. Egyptians
had many genetic polymorphism related to NAFLD incidence
and disease severity, in Egyptian obesity, and
highest insulin resistance as main risk factors for NAFLD
even in non-diabetics, and deficient conjugated linolenic
acid had a role in NASH progression, also modification
of intestinal microbiota is a must to improve NAFLD
