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Abstract

Krabbe's disease, a rare lysosomal storage disorder caused by galactosyl ceramidase deficiency, manifests with severe neurodevelopmental consequences, impacting both the central and peripheral nervous systems. This article explores the early markers and intervention strategies aimed at mitigating the neurodevelopmental impact of Krabbe's disease. Through a comprehensive review of current research findings, clinical studies, and emerging biomarkers, the article aims to provide insights into the progressive nature of the disease and avenues for timely intervention. The discussion encompasses genotype-phenotype correlations, neurocognitive and motor impairments, and challenges in early detection and intervention, ultimately emphasizing the urgency of a holistic approach to address the complex neurodevelopmental landscape in Krabbe's disease