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Abstract

Bovine tuberculosis diagnosis is one of the main challenges faced by animal and public health systems. The incidence of M. bovis infections remains undefined in developed countries. So it is necessary to carry out an extensive study and surveillance to determine the status of bovine tuberculosis as an urgent need for control eradication program. Furthermore, developed countries, microbiological (bacteriological) and immunological (histochemistry) techniques are still used, making more difficult to homogenize epidemiological knowledge of bTB. Recent reports describing the potential of microarray technology not only to explore subunit vaccine agents (biomarkers), but to pinpoint immunomodulation, and signatures in the journey of pathogen interaction with the host in bovine tuberculosis. Omics and next generation high-throughput technologies have risen as promising tools that will enable translational research (development of prognostic and diagnostic methods with high accuracy and sensibility) and in depth molecular analysis even at single cell level to underpin dynamics in the transcripts regulation of the host response in bTB.

Keywords: Bovine tuberculosis; M. bovis ; RNA seq; Transcritptomic; Genomics; Omics technologies; Printing signatures; Gene expression profiles