Research Article
Risk Factors Associated with Helicobacter Pylori Infections in Makurdi Northcentral Nigeria
Mnena EY1*, Ebele U1 and Emmanuel N2
1Department of Biological Sciences, Federal University of Agriculture, Makurdi, Benue State, Nigeria
2Safety Molecular Pathology Laboratory, Plot 44 Rangers Avenue, Independence Layout Enugu, Nigeria
- *Corresponding Author:
- Yaji Mnena E
Department of Biological Sciences
Federal University of Agriculture
Makurdi, Benue State, Nigeria
Tel: 07030695000
E-mail: Yajimnena@gmail.com
Received date: May 30, 2017; Accepted date: July 18, 2017; Published date: July 24, 2017
Citation: Mnena EY, Ebele U, Emmanuel N (2017) Risk Factors Associated with Helicobacter Pylori Infections in Makurdi Northcentral Nigeria. J Infect Dis Ther 5:325. doi: 10.4172/2332-0877.1000325
Copyright: © 2017 Mnena EY, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Background: Helicobacter Pylori (H. pylori) is a microaerophilic bacterium that inhabits the gastric mucosa of the human stomach. Infection with this bacterium leads to chronic gastritis, peptic ulceration, gastric cancers and gastric malt lymphoma. Studies have documented a higher prevalence in Africa and the transmission pathways are still vaque.
Methods: Eighty gastric biopsies were collected from the antrum of patients referred for endoscopy. Informed consent was obtained and questionnaires on risk factors such as type of water used, foods and habitswere administered to them. Genomic DNA was extracted from the tissue samples using ReliaPrep genomic DNA miniprep kit (Promega, Southampton UK), and H. pylori DNA was detected using a Singleplex PCR of the 16S rRNA gene.
Results: Of all the parameters analyzed, only involvement in milking of cows (OR=3.545, 95% CI: 2.488-5.052; p=0.029) and sharing of spoons and cups (OR=45.00, 95% CI: 8.769-230.936; p <0.001) had significant association with transmission, and patients were at increased risk of infection.
Conclusion: Transmission of H. pylori may be associated with the risk factors related to hygiene. Adequate hygiene is advocated to reduce the scourge of the infection.
