Role of Inorganic Polyphosphate in Promoting Persistence of Mycobacteria
Received Date: Dec 12, 2023 / Published Date: Dec 13, 2023
Abstract
In recent paper, He, et al., elegantly demonstrate the role of inorganic plyphospahte (polyP) in promoting persistence of Mycbacteria. Firstly, polyP affects the formation, morphology and ultramicrostructure of biofilms of Mycobacterium smegmatis by affecting the synthesis of short chain fatty acids. Furthermore, polyP regulates inflammatory factors expression through transition of macrophages from M1 to M2 type and promotes the survival of M. smegmatis in cells. Tuberculosis is still the main threat to human health. Persistence is an important cause of drug resistance and recurrence for M. tuberculosis.
Keywords: Polyphosphate; Mycobacteria; Hydrophobicity; Mutation
Citation: Gong H, Wang J, Shi T (2023) Role of Inorganic Polyphosphate in Promoting Persistence of Mycobacteria. J Infect Dis Ther 11:570. Doi: 10.4172/2332-0877.1000570
Copyright: © 2023 Gong H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original author and source are credited.
Share This Article
Recommended Journals
黑料网 Journals
Article Tools
Article Usage
- Total views: 617
- [From(publication date): 0-2023 - Nov 25, 2024]
- Breakdown by view type
- HTML page views: 554
- PDF downloads: 63
