Research Article
Safety of Blood Transfusion: An Egyptian Study
| Dalia Omran1*, Eiman A Hussein2 and Mohamad Nagib3 | ||
| 1 Department of Tropical Medicine, Cairo University, Egypt | ||
| 2 Departments of Clinical Pathology and Hepatology, Cairo University, Egypt | ||
| 3 Department of Internal Medicine, Cairo University, Cairo, Egypt | ||
| Corresponding Author : | Dalia Omran Faculty of Medicine Department of Tropical Medicine Cairo University, Nasr City, Egypt Tel: +(202)01000087802 Fax: +(202)23649281 E-mail: daliaomran2007@yahoo.com |
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| Received December 04, 2013; Accepted December 13, 2013; Published December 17, 2013 | ||
| Citation: Omran D, Hussein EA, Nagib M (2013) Safety of Blood Transfusion: An Egyptian Study. J Infect Dis Ther 1:124. doi: 10.4172/2332-0877.1000124 | ||
| Copyright: © 2013 Omran D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | ||
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Abstract
Introduction: Blood safety presents a serious challenge in Egypt, having the highest prevalence of C virus (HCV).
Objectives: To evaluate the effectiveness of blood donor recruitment strategies, the seroprevalence of positive infectious markers among volunteer donors (VD) and family replacement donors (RD) at a University Hospital Blood Bank was studied.
Methodology: Donors’ records covering the period between 2006 and 2012 were reviewed. All donations had been tested using the following screening tests ; Ortho for HCV antibody (enzyme-linked immunosorbent assay test system Version 3.0, Ortho Clinical Diagnostics, Inc., Raritan, NJ) and Siemens (Siemens Enzygnost assay, Healthcare Diagnostic Products, Marburg, Germany) for HBsAg (Enzygnost HBsAg 6.0), (HIV)-1 and HIV-2 antibodyies (Enzygnost HIV integral II), and syphilis antibodies. Reactive samples were not confirmed with additional tests.
Results: Of 308,762 donors, 63.4% were VD. The overall prevalence of HCV antibodies, HBsAg, human immunodeficiency virus (HIV) and syphilis antibodies were 4.3%, 1.22%, 0.07%, and 0.13%, respectively. After stratification for age and gender, all tested markers (except HIV) were significantly higher among RD.A significant decline in HCV seropositivity was observed in RD and VD from 8.9% and 4.2% in 2007/2008 to 3.8% and 1.5% in 2011/2012, respectively. A significant decrease in HBsAg was demonstrated in VD from 1.2% in 2007/2008 to 0.53% in 2011/2012. During the period 2007- 2011, an increasing trend for HIV and syphilis was noted.
Conclusion: The decreasing trend in HCV antibodies and HBsAg could be related to the strict donor selection criteria.
