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Abstract

Thiamine deficiency disorders, exemplified by Wernicke-Korsakoff Syndrome (WKS), pose significant challenges to neurological health. This abstract delves into the intricate complexities surrounding thiamine deficiency and its implications for WKS and related conditions. Thiamine, an essential micronutrient crucial for energy metabolism and neurotransmitter synthesis, plays a pivotal role in maintaining neurological function. WKS encompasses acute Wernicke's encephalopathy and chronic Korsakoff's psychosis, reflecting the diverse manifestations of thiamine deficiency on the brain. Mechanistically, thiamine deficiency disrupts energy production, induces oxidative stress, and triggers neuroinflammatory cascades, culminating in neuronal damage and cognitive impairment. Diagnosis of WKS remains challenging due to its varied clinical presentation and lack of specific biomarkers. Early detection and intervention with thiamine supplementation are critical for halting disease progression, highlighting the importance of heightened awareness and targeted public health initiatives to address the thiamine crisis.