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Abstract

This study employs untargeted metabolomics to investigate the urinary metabolic profiles associated with acute and chronic gout. By analyzing urine samples from individuals diagnosed with both forms of the condition, we identified distinct metabolic signatures that differentiate acute flares from chronic manifestations. Our findings reveal alterations in key metabolites linked to purine metabolism, inflammation, and oxidative stress, providing insights into the biochemical pathways affected in gout. This research enhances our understanding of gout's metabolic underpinnings and may pave the way for novel diagnostic and therapeutic strategies.