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Abstract

A novel zirconia nanoparticles based electrochemical sensor has been developed via drop casting method and the electrochemical sensor was characterized with scanning electron microscopy (SEM). The electrochemical behaviour of ethionamide (ETA) at zirconia modified glassy carbon electrodes (GCEs) were investigated by cyclic voltammetry (CV) and square-wave voltammetry (SWV) and results indicated that the electrode process is diffusion controlled. The decrease of charge transfer resistance was also analysed by electrochemical impedance spectroscopy. Under the optimal conditions, the peak current of SWV increased linearly with the ETA concentration in the range from 150 - 650 ng/mL with a limit of detection (LOD) 47.66 ng/mL and its application for the electrochemical detection of ethionamide (ETA) in solubilized system has also been reported. Keywords: ZrO 2 /GCE; ETA; Voltammetry; Pharmaceutical formulation.

Biography

Rajeev Jain completed his B.Sc. and M.Sc. from Meerut University, Meerut (Now C.C.S. University, Meerut) and Ph.D. in Chemistry from the University of Roorkee (now Indian Institute of Technology, Roorkee), India, in 1978. He is a highly cited researcher in Electroanalytical and Environmental Engineering Chemistry. He has published over 273 research papers in journals of international repute with high impact factor. He has supervised over 60 Ph.D. and one D.Sc. student. He is a widely traveled researcher and has worked over on 15 research projects sanctioned by CSIR, UGC, MOEF, and DRDO etc. His research interests include electroanalytical behaviour of pharmaceuticals, micellar catalysis, electrocatalysed reactions, method development and validation, environmental engineering chemistry and wastewater treatment.