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Abstract

In Georgia, significantly huge number of patients with Diabetes Mellitus Type 2 (DMT2) suffers from Cardio-Vascular Diseases (CVD) and obesity. Since, dyslipidemia is one of major factors leading to CV-mortality, it is crucial to investigate the effects of relatively novel hypoglycemic agents-Sodium Glucose co- Transporter 2 (SGLT2) (Dapagliflozin) or Glucagon Like Peptide 1 (GLP-1) agonists (Liraglutide) on lipid profile. The aim of our observational study was to assess the benefits of these two medications among the patients with DMT2 and dyslipidemia. Methodology: A total of 68 persons with T2DM, (mean age 51.8 �± 6.1. mean duration of diabetes �± 10.3 yrs) were recruited in the study. All of them were treated with GLP1 agonists or SGLT2 inhibitors (35 patient with SGLT2 inhibitors, 33 patients with GLP1 agonists) as add on therapy to Metformin. We paid serious attention to dietary recommendations and physical activity in all patients. We compared the effects of GLP-1 agonists and SGLT2 inhibitors on lipid profile at baseline and after 18 weeks. Anova test was used to see the differences in groups. Results: 62 patients completed the follow-up. After 18 weeks of the treatment, the study showed the upward trend of Total Cholesterol (CH), HDL-Cholesterol (HDL-CH) and LDL-cholesterol (LDLCH) among patients treated with SGLT2 inhibitors-Median LDLCH +0.2 mmol/l, Median total CH +0.2 mmol/l and Median HDLCH +0.3 mmol/l. Median LDL-CH was reduced (-0.2 mmol/l)) among the patients, treated with GLP-1 agonists. However, there was no significant effect shown on HDL-CH or total Cholesterol. Mean levels of Triglycerides (TG) remained unchanged in the both groups. Findings: We think that different impacts of hypoglycemic medications on lipid profile seen in our patients should be taken in concern and outlined. The SGLT-2 inhibitor was associated with increase of both- HDL-CH and LDL-CH, while GLP-1 agonists with reduction of LDL-CH. However these are short-term observational study results, we do hope to investigate accurately the whole lipid profile among our patients for the following months.

Biography

Nestan Bostoganashvili has finished Tbilisi State Medical University in Tbilisi Georgia. She has worked as Intern on the basis on National Institute of Endocrinology, She has completed dissertation on “Growth hormone replacement therapy effect on the lipid profile in growth hormone deficient adults”. She is the first author of several publications, since the first day of her practice; she is interested in different fields of Endocrinology: Diabetes Mellitus, Pituitary-hypothalamic axis, obesity. She is the member of National Nutritionists association. She is assistant professor in different Universities of Georgia.