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Abstract

The advancement of hyphenated instrumentation from a wide range of academic, governmental, and industrial researchers in the form of liquid chromatography (LC) being coupled to mass spectrometry (MS) has continued to develop into a powerful multi-dimensional hyphenated instrumental technology for the use in a wide assortment of analytical and bioanalytical techniques. Examples of this development can be seen in the analysis of nucleic acids, amino acids, peptides, proteins, carbohydrates, lipids, and etcetera and/or in the more comprehensive analysis of biological information in the various omics fields such as genomics, proteomics, metabolomics, lipidomics, and etcetera. This advancement in hyphenated LC-MS instrumentation has been historically and still is presently driven by the need for a more powerful analytical and bioanalytical techniques that can accurately and precisely discriminate target analytes from high complexity mixtures in a sensitive and selective way from within a concise window of time. With this in mind, this presentation which is based upon a recent editorial, briefly attempts to highlight some of the current trends in hyphenated LC-MS instrumentation available today and their respective contributions to the field of analytical and bioanalytical techniques.

Biography

Wes E. Steine has Ph.D. in Analytical Chemistry from Washington State University with focus on the development and use of analytical instrumentation to explore a variety of topics involving health, environment, agriculture, and defense. Presently his research group is focused on the qualitative discovery and quantitative directed analysis of bio-markers that can be correlated to a specific disease trait, state, and/or rate. He has participated in obtaining more than 14 grants, the publication of more than 25 publications, and the presentation of more than 63 presentations.