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ISSN: 2155-952X

Journal of Biotechnology & Biomaterials
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Effect of Melissa officinalis on rat hippocampal and cortex slices subjected to oxygen and glucose deprivation

2nd World Biotechnology Congress

Mushtaq Ahmed

UST-Bannu, Pakistan

Posters & Accepted Abstracts: J Biotechnol Biomater

DOI:

Abstract
Cerebral stroke is 3rd leading cause of death after cancer and heart attack worldwide. Free radicals play key role in brain injury. The results of the present investigation demonstrate that Oxygen-glucose deprivation (OGD) followed by re-oxygenation led to cell damage/death via an increase in free radical芒�?�?s production in rat brain hippocampal and cortex slices compared with control (non-OGD) after 2h OGD followed by 1h reperfusion. Melissa officinalis at concentration 40 �?碌g/ml displayed potential role in neuro-protection against OGD, followed by re-oxygenation in mitochondrial viability assays in vitro. In addition, Melissa officinalis decreased or slowdown the production free radical in the supernatant and slices homogenate of hippocampal and cortex at the end of 2h OGD followed by 1h reperfusion. Furthermore, higher concentrations of Melissa officinalis slightly showed neurotoxicity for hippocampal and cortex slices which could be due to a pro-oxidant effect.
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