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Abstract

Disease Management and prognostication of aplastic anemia (AA) depends on etiology i.e. constitutional vs. acquired. Mitomycin-C induced stress cytogenetics distinguishes between the two. Th ere is scant data on the demographic distribution, etiology and prevalence of constitutional aplasia in India. Peripheral blood samples from 300 patients were processed for chromosomal breakage study. Patients were examined for the presence of phenotypic features of constitutional aplastic anemia. Hemogram, bone-marrow biopsy results and data of demographic distribution and infectious etiology were documented. Th e incidence rate of AA was 1.97 cases per million per year. Th e male to female sex ratio was 3.2:1. Strong association between survival rate and severity was found with hazard ratio 0.39. Hepatitis infection was also observed frequently among patients (odds ratio, OR: 0.99; 95% confi dence interval, CI: 0.99-1.00). In this cohort, 9.40% had evidence of constitutional aplastic anemia. In view, of the high mortality rate and therapeutic implications, it should be mandatory for all patients with aplastic anemia to undergo this investigation prior to initiation of therapy. Th e skewed sex ratio in our study probably refl ects the gender bias in our society. Higher percentage of AA cases was observed in northern states of India viz. Bihar, Delhi/NCR & Uttar Pradesh.

Biography

I, Dharmendra Jain, is working as a Scientist at Molecular Genetics & Immunology laboratory of Medanta, The Medicity Hospital, Gurgaon Haryana, India and and a registered Ph.D candidate of Amity Institute of Biotechnology, Amity University, Uttarpradesh, India.