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Abstract

Mass spectrometry (MS) is gaining priority as analytical tool to analytical/organic/ pharmaceutical chemists and biologist due to its appealing features like ease of sample preparation, operational simplicity and ease of spectral interpretation. Reactions are the heart and soul of chemistry 1 and mass spectrometric technique holds the place at the crucial stage of analysis such as structural confi rmation, purity determination, and conversion. Oft en interpretation/prediction of the desired product depends upon the understanding of the reaction mechanism. Th e MS techniques particularly ESIMS is a solution provider towards this end through ?ion fi shing? of charged species as reactive intermediates. 2 However, revealing reaction pathways that proceed through noncovalent short lived species remains the challenging task and MALDI and ESI MS techniques are being increasingly used 3-5 for the purpose that adds a new dimension to analytical techniques. Th is presentation will summarise about a special application of ESI-MS to ?fi sh? the noncovalent complex/ion directly from solution phase to gas phase that gives insight into the reaction mechanism and proves it on the basis of trapped reactive intermediate.

Biography

Naisargee Parikh, a current Ph. D scholar from department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), India involved in the design and synthesis of anti- asthmatic drugs. She has completed her M.S. (Pharm.) from NIPER, India and having one patent and two papers published in international journals.