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Modeling and docking studies of DKK-1, a novel receptor in HCC pathway
6th World Congress on Biotechnology
Sandhya Hora Wadhawan and Deepshikha Pande Katare
Amity University, India
Posters-Accepted Abstracts: J Biotechnol Biomater
DOI:
Abstract
Hepatocellular carcinoma (HCC) is the fifth malignant tumor and the second leading cause of cancer related mortality worldwide. The major reason for high prevalence of HCC is poor diagnosis at early stage. Prognostic biomarkers of HCC are still not absolutely ready for introduction into clinical trials because they have restricted sensitivity and specificity. Serum Dickkopf-1 (DKK1) plays an important role in HCC progression which is a secretory protein in Wnt/�?虏-catenin signaling pathway. The sensitivity and specificity of DKK1 are good to diagnose HCC. The 3-D structure of DKK1 was modeled and used for docking against various compounds extracted from marine organisms. These compounds have anti-cancerous activities and some of them are already in clinical trials. The compound with best binding energies will be taken forward to design inhibitors of DKK1.Biography
Sandhya Hora Wadhawan is a PhD Scholar in Centre for Medical Biotechnology, Amity Institute of Biotechnology, Amity University and has completed her Master’s in Biotechnology from Chaudhary Charan Singh University, Meerut. She has worked as a Research Assistant in SRMS-Institute of Medical Sciences, Bareilly for two years and published 3 papers in reputed national journals.
Email: sandhya.hora@gmail.com
