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In Association with
PPARG: A possible target for type-2 diabetes induced Dementia
6th World Congress on Biotechnology
Khyati Mittal and Deepshikha Pande Katare
Amity University, India
Posters-Accepted Abstracts: J Biotechnol Biomater
DOI:
Abstract
Type-2 Diabetes Mellitus (T2DM) is the most complex and rising disease in the recent years. It is believed that T2DM is associated with various diseases in which dementia is the major one. Studies have reported that diabetes increase the risk of dementia by 1.5 to 2 fold. In the etiology of diabetes induced dementia/cognitive impairment, inflammatory markers, disturbed immune response and increased apoptosis plays a critical role in the production of oxidative stress in the peripheral tissues. To manage these challenges, it is required to incorporate flavonoids, terpenoids & alkaloids in our diet. This will suppress neuroinflammation and promote memory learning and cognitive functions. In the current study, we have developed a map that represents the progression of T2DM to dementia by using differentially expressed proteins. It was observed that PPARG plays a crucial role in transferring T2DM to dementia. We have also docked PPARG receptor with flavonoids along with marketed drug of T2DM for further drug designing targeting T2DM induced dementia.Biography
Khyati Mittal has completed her MSc in Industrial Chemistry and she is currently pursuing PhD in Biotechnology in Amity University, Uttar Pradesh. Her area of specialization is Pharmaceutical Biotechnology. She has one publication in International Journal of Pharmaceutical Science Research and Review.
Email: khyatimittal19@gmail.com
