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Depression and anxiety are highly prevalent and represent a significant and well described public health burden. Whilst
first line psychological treatments are effective for nearly half of attenders, there remain a substantial number of patients
who do not benefit. The main objective of the present project is to establish an infrastructure platform for the identification of
factors that predict lack of response to psychological treatment for depression and anxiety, in order to better target treatments
as well as to support translational and experimental medicine research in mood and anxiety disorders. Predicting outcome
following psychological therapy in IAPT (PROMPT) is a naturalistic observational project that began patient recruitment in
January 2014. The project is currently taking place in Southwark Psychological Therapies Service, an Improving Access to
Psychological Therapies (IAPT) service currently provided by the South London and Maudsley NHS Foundation Trust (SLaM).
However, the aim is to roll-out the project across other IAPT services. Participants are approached before beginning treatment
and offered a baseline interview whilst they are waiting for therapy to begin. This allows us to test for relationships between
predictor variables and patient outcome measures. At the baseline interview, participants complete a diagnostic interview; are
asked to give blood and hair samples for relevant biomarkers, and complete psychological and social questionnaire measures.
Participants then complete their psychological therapy as offered by Southwark Psychological Therapies Service. Response to
psychological therapy will be measured using standard IAPT outcome data, which are routinely collected at each appointment.
This project addresses a need to understand treatment response rates in primary care psychological therapy services for those
with depression and/or anxiety. Measurement of a range of predictor variables allows for the detection of bio-psycho-social
factors which may be relevant for treatment outcome. This will enable future clinical decision making to be based on the
individual needs of the patient in an evidence-based manner. Moreover, the identification of individuals who fail to improve
following therapy delivered by IAPT services could be utilized for the development of novel interventions.
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