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ISSN: 2167-065X

Clinical Pharmacology & Biopharmaceutics
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Tetsuro Urushidani

Japan
Publications

Transport Mechanism of Intestinal Absorption of μ Opioid Receptor Agonists and Contribution of P-Glycoprotein in Rats and Human Intestinal Epithelial Caco-2

Abstract 1.1. Introduction: The μ opioid receptor agonists, morphine and loperamide, are widely used orally and are suggested to be P-glycoprotein (P-gp) substrates. P-gp is expressed in the brain, intestine, and various tissues in human and rats. In the intestine, P-gp limits the absorption of certain drugs such as opioids; however, the under... Read More»

Kazumasa Naruhashi, Akiko Kamino, Ena Ochi, Erina Kusabiraki, Megumi Ueda, Yuusuke Sugihara, Tetsuro Urushidani, Hirokazu Nakanishi and Nobuhito Shibata

Research Article: Clin Pharmacol Biopharm 2016, 5:154

DOI:

Abstract Peer-reviewed Full Article Peer-reviewed Article PDF

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