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Changing Trends of Liver Diseases in Benin City, A Twenty (1985-2004) Years Comparative Histopathology Study

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Aim: The aim of this study is to determine the pattern chronic liver diseases histologically diagnosed in the
University of Benin Teaching Hospital between 1985and 2004 and compare with previous study of histopathological
diseases of the liver in a previous study.
Methodology: The surgical daybooks, histopathology request and report forms were the sources of data used for
this study. All liver biopsies received at the Department of Pathology, University of Benin Teaching Hospital, Benin City,
Edo State, Nigeria, from January 1985 to December 2004were reviewed.
Results: A total of 235 liver biopsies were received in the Department of Histopathology, University of Benin
Teaching Hospital, Benin City during the period under review. The commonest hepatic disease was viral hepatitis 78
cases (33.19%). Followed byhepatocellular carcinoma 59 cases (25.10%), 33 cases (14.04%) of cirrhosis, 26 cases of
metastatic tumors to the liver (11.06%), five cases (2.13%) of primary biliary cirrhosis, four cases (1.70%) of alcoholic
liver disease, three cases (1.28%) of neonatal hepatitis, hepatoblastoma, fatty change and Non-Hodgkin lymphoma
respectively; two cases (0.85%) of cholangiocarcinoma, haemangioendothelioma, sarcoidosis, and neonatal giant cell
hepatitis respectively and one case (0.43%) each of glycogen storage disorder, extrahepatic biliary atresia, fulminant
hepatitis, hepatic abscess, congenital hepatic fibrosis, polycystic hepatic disease, cavernous haemangioma and
hepatic cholestasis.
Conclusion: The predominant liver diseases were inflammatory diseases(50.22%), malignant neoplasm(40.42%),
biliary tract disorders (2.99%) and metabolic disorders (2.56%).

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