Case Report
Full Clinical and Endoscopic Remission Following Fecal Microbiota Transplant with Moderate-Severe Treatment-Resistant Ulcerative Colitis
Mihaela Laszlo1* and Pascu O1,2
1Regional Hepatology and Gastroenterology Institute, Cluj-Napoca, Romania
2University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania
- *Corresponding Author:
- Mihaela Laszlo
Regional Hepatology and Gastroenterology Institute
Cluj-Napoca, 8 Babes Street, 400012 Cluj-Napoca, Romania
Tel: +40-264-597-256
Fax: +40-264-597-257
E-mail: miham83@yahoo.com
Received date: March 11, 2014; Accepted date: April 25, 2014; Published date: April 30, 2014
Citation: Laszlo M and Pascu O (2014) Full Clinical and Endoscopic Remission Following Fecal Microbiota Transplant with Moderate-Severe Treatment-Resistant Ulcerative Colitis. J Gastroint Dig Syst 2:183. doi:10.4172/2161-069X.1000183
Copyright: © 2014 Laszlo M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Fecal microbiota transplantation (FMT) from healthy donors, is an effective alternative for treatment of Clostridium difficile–associated disease, it is being considered for several disorders such as inflammatory bowel disease, irritable bowel syndrome, and metabolic syndrome.
A 61 year old male with extensive ulcerative colitis since 2010 under biologic therapy from 2012 and with several acute relapses under treatment. The patient has been treated with FMT, clinical and biological remission was achieved.
This case highlights the value of characterizing temporally resolved microbiota dynamics for a better understanding of FMT efficacy and provides potentially useful diagnostic indicators for monitoring FMT success in the treatment of ulcerative colitis.
FMT seems to be a promising alternative treatment of frequent relapses for selected cases of ulcerative colitis
