Research Article
Incidental Cholangiocarcinoma is Associated with Poor Outcome in Patients Transplanted for Hepatocellular Carcinoma
Rustam Khan1,2, Safia Awan2, Peng Chung Cheow1, Chee Kiat Tan1 and Pik Eu Chang1*
1Department of Gastroenterology and Hepatology, Singapore General Hospital, Outram Road, 169608, Singapore
2Aga Khan University Hospital, Stadium Road, Karachi 74800, Pakistan
- *Corresponding Author:
- Dr. Jason Chang Pik Eu
Department of Gastroenterology and Hepatology
Singapore General Hospital
Outram Road, 169608, Singapore
Tel: (+65) 6321 4684
Fax: (+65) 6227 3623
E-mail: jason.chang@sgh.com.sg
Received date: July 15, 2015 Accepted date: August 12, 2015 Published date: August 18, 2015
Citation:Khan R, Awan S, Cheow PC, Tan CK, Chang PE (2015) Incidental Cholangiocarcinoma is Associated with Poor Outcome in Patients Transplanted for Hepatocellular Carcinoma. J Gastrointest Dig Sys 5:322. doi:10.4172/2161-069X.1000322
Copyright: © 2015 Khan R et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License; which permits unrestricted use; distribution; and reproduction in any medium; provided the original author and source are credited.
Abstract
Background: Hepatocellular carcinoma (HCC) is a common malignancy in Asia for which orthotopic liver transplantation (OLT) offers curative treatment in selected patients. Incidental HCC-cholangiocarcinoma (HCC-CLC) has been associated with poor OLT outcomes. Aims: To examine the prevalence of incidental HCC-CLC in liver explants from patients undergoing liver transplantation for HCC in our center and to examine its association with post-transplant disease recurrence and mortality. Methods: Medical records of all liver transplant patients in our center were reviewed. The presence of HCC-CLC in liver explants was reviewed by experienced pathologists. Factors associated with recurrence of HCC post OLT and post-transplant mortality were analyzed. Survival in patients with incidental HCC-CLC was compared against those without.
