Research Article
Lipoprotein Lipase Activation Improve the Cachexia and Obesity
| Masataka Kusunoki1*, Kazuhiko Tsutsumi2, Chen Tana3, Daisuke Sato4 and Takao Nakamura4 | |
| 1Department of Internal Medicine, Medical Clinic, Aichi Medical University, Nagoya, Japan | |
| 2Okinaka Memorial Institute for Medical Research, Tokyo, Japan | |
| 3Department of Sports Medicine, Graduate School of Medicine, Nagoya University, Nagoya, Japan | |
| 4Department of Biomedical Information Engineering, Graduate School of Medical Science, Yamagata University, Yamagata, Japan | |
| Corresponding Author : | Masataka Kusunoki Department of Internal Medicine Medical Clinic, Aichi Medical University 2-12-1, Higashisakura, Higashi-ku Nagoya 461-0005, Japan Tel: +81-52-931-2261 Fax: +81-52-931-4841 E-mail: info@tonyo.jp |
| Received May 20, 2013; Accepted May 31, 2013; Published June 03, 2013 | |
| Citation: Kusunoki M, Tsutsumi K, Tana C, Sato D, Nakamura T (2013) Lipoprotein Lipase Activation Improves the Cachexia and Obesity. J Obes Weight Loss Ther 3:177. doi:10.4172/2165-7904.1000177 | |
| Copyright: © 2013 Kusunoki M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
Abstract
Cachexia is defined as an extreme wasting condition with marked weight loss. It is observed in paints with cancer and severe infectious disease. Obesity is one of the fasted growing major diseases in developed and developing countries. As has been persuasively argued, long-term imbalance between intake and expenditure of fat is a central factor in the etiology of obesity. We hypothesized that elevating lipoprotein lipase (LPL) activity would cause an improvement of cahexia and obesity. To test this hypothesis, we studied the effects of the LPL activator NO-1886 in cachexia and obese animals.
