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Research Article

Proton-Pump Inhibitor Treatment in Eosinophilic Esophagitis is Associated with Decreased Eosinophil Degranulation

Division of GI, New York University Langone Medical Center, Pediatrics, 160 east 32nd street New York, NY 10016, USA

*Corresponding Author:

Jeremiah Levine
Division of GI, New York University Langone Medical Center
Pediatrics, 160 east 32nd street New York, NY 10016, USA
Tel: 12122635407
Fax: 12122635417
E-mail: jeremiah.levine@nyumc.org

Received date: January 13, 2015; Accepted date: February 16, 2015; Published date: February 25, 2015

Citation: Levine J, Lu Y, Carreon CK, Edelman M (2015) Proton-Pump Inhibitor Treatment in Eosinophilic Esophagitis is Associated with Decreased Eosinophil Degranulation. J Gastrointest Dig Syst 5:259. doi:10.4172/2161-069X.1000259

Copyright: © 2015 Levine J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Eosinophilic esophagitis (EoE) is an increasingly recognized disorder whose diagnosis is based on histologic demonstration of eosinophilic inflammation. We previously reported improvement of symptoms in children with EoE on long-term proton-pump inhibitor (PPI) monotherapy despite persistent eosinophilic inflammation. We sought to determine whether PPI monotherapy in children with EoE is associated with decreased eosinophil degranulation. Ten children with EoE had esophageal biopsies assessed for eosinophil, mast cell and Langerhans cell concentration and eosinophil degranulation at diagnosis and following PPI treatment. There was no significant difference in cell concentrations between initial and one-year follow-up. A significant decrease in number of free lying granules was observed at the one-year follow-up biopsies. Prolonged PPI therapy in EoE is associated with decreased eosinophil degranulation.

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