Research Article
Resection of Pancreas and Duodenum During Radical Nephrectomy: Analysis of A Single Center Experience
Juan Chipollini1 and Gaetano Ciancio1,2*
1Department of Urology, University of Miami Miller School of Medicine, Miami, Florida, USA
2Department of Surgery, Division of Transplantation, Miami Transplant Institute, University of Miami Miller School of Medicine, Jackson Memorial Hospital, Miami, Florida, USA
- Corresponding Author:
- Gaetano Ciancio
M.D., University of Miami Miller School of Medicine
Department of Surgery and Urology, University of Miami Miller
School of Medicine, Jackson Memorial Hospital, Miami Fl
Miami Transplant Institute, P.O. Box 012440, Miami, Fl 33101, USA - Tel: (305) 355-5460
Fax: (305) 355-5797
E-mail: gciancio@med.miami.edu
Received date: February 26, 2016; Accepted date: April 25, 2016; Published date: April 29, 2016
Citation: Chipollini J, Ciancio G (2016) Resection of Pancreas and Duodenum During Radical Nephrectomy: Analysis of A Single Center Experience. J Gastrointest Dig Syst 6:420. doi:10.4172/2161- 069X.1000420
Copyright: © 2016 Chipollini J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Introduction: To analyze our experience of radical nephrectomy (RN) with en-bloc resection of neighboring organs for T4 renal cell carcinoma (RCC) based on our experience with multivisceral transplantation techniques.
Materials and Methods: After Institutional Review Board approval, a retrospective review was performed for patients who underwent RN and resection of adjacent organs and with a minimum follow up of 6 months.
Results: Ten patients underwent RN along with resection of pancreas (80%) and 2nd portion of duodenum (30%). Other organs simultaneously removed were inferior vena cava (IVC) (30%), spleen (70%), adrenal (100%), and left colon (10%). Major complications (Clavien-Dindo grade ≥ III) were seen in 6 patients (60%). The overall recurrence rate was 70%.The 2-year overall survival (OS) was 42.9 ± 13% and 2-year disease free survival (DFS) 28.6 ± 4.6%.
Conclusions: Those patients that undergo complete resection of T4 RCC face a high recurrence rate, but some have potential for durable survival response. Multi-institutional studies are needed to determine those patients that may benefit from aggressive surgical interventions, and should be considered for clinical trials of adjuvant targeted therapies.
