Review Article
Role of Gastric Acid in Dyspepsia
Samal SC1*, Pratap Behera1 and George M Chandy2
1Department of GI and Liver Sciences, Amri Hospitals, Khandagiri, Bhubaneswara, Odisha, India
2MIOT Advanced Center for GI and liver diseases, Chennai, India
- *Corresponding Author:
- Subash Chandra Samal M.D, DM
Department of GI And Liver Sciences, Amri Hospitals
Khandagiri, Bhubaneswara, Odisha, India
Tel: 91-9938756409
E-mail: subashsamal@hotmail.com
Received date: March 01, 2015; Accepted date: April 01, 2015; Published date: April 08, 2015
Citation: Samal SC, Behera P, Chandy GM (2015) Role of Gastric Acid in Dyspepsia. J Gastrointest Dig Syst 5:280. doi:10.4172/2161-069X.1000280
Copyright: © 2015 Samal SC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Functional dyspepsia is a clinical syndrome in which there is an absence of underlying organic disease to explain the symptoms. Empiric acid suppression is one among the many options available in the therapeutic armamentarium to treat this common condition. However the response to acid suppression is not always a consistent one. It is because of the heterogeneous nature of the pathophysiologic mechanisms involving gastric acid in this scenario. This variation in the role of the gastric acids is determined possibly by the genetic constitution and it is influenced by the factors like H. pylori infection, irritants, allergens and diet. All these events primarily lead to visceral hypersensitivity. Finally, it is the degree of affection, whether gastric or duodenal, decides its clinical presentation. If it is a predominant gastric visceral hypersensitivity, presentation would be of Rome III-EPS type, whereas duodenal sensitisation would present as Rome III-PDS.
