Research Article
Sleeve Gastrectomy Ameliorates Mrna Expression of Matrix Metalloprotease I, III, V, IL-1a and IL-6 Genes in Substantia Nigra Tissues of Obese Rats
| Inan Gezgin*, Cem Ozic, Can Hakan Y脙鈥灻偮眑d脙鈥灻偮眗脙鈥灻偮眒, Kemal Kilic, Yusuf Ehi and Miktat Kaya | |
| Department of Neurosurgery, Private Park Hospital, Ad脙鈥灻偮眣aman, Turkey | |
| Corresponding Author : | Inan Gezgin Department of Neurosurgery Private Park Hospital, Ad脙鈥灻偮眣aman, Turkey Tel: 416 7255066 Fax: 7256502 E-mail: drigezgin1978@ hotmail.com |
| Received December 05, 2015; Accepted January 12, 2016; Published January 15, 2016 | |
| Citation:Gezgin I, Ozic C, Y脙鈥灻偮眑d脙鈥灻偮眗脙鈥灻偮眒 CH, Kilic K, Ehi Y, et al. (2016) Sleeve Gastrectomy Ameliorates Mrna Expression of Matrix Metalloprotease I, III, V, IL-1a and IL-6 Genes in Substantia Nigra Tissues of Obese Rats. J Obes Weight Loss Ther 6:294. doi:10.4172/2165-7904.1000294 | |
| Copyright: © 2016 Gezgin I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
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Abstract
Aim: To reveal metalloproteinase (MMP)-1, MMP-3, MMP-5, interleukin (IL)-1a and IL-6 gene expressions in substantia nigra region of brain in rats which undergone sleeve gastrectomy (SG) surgery. Methods: Rats were allocated into three groups in random, which were normal rats (Group I) (n=14), obese rats (Group II) (n=14), and obese rats subjected to SG (Group III) (n=14). MMP-1, MMP-3, MMP-5, IL-1a and IL-6 gene expressions were determined by polymerase chain reaction (PCR) and Real-time polymerase chain reaction (RTqPCR). Results: When normal (Group I), and obese (Group II) rats were compared, a decrease in expressions of MMP- 3 and IL-6 genes was observed in Group II. When obese rats (Group II) and obese rats subjected to SG (Group III) were compared, increases in the expressions of MMP-3 and IL-6 genes were observed in Group III. This phenomenon demonstrates that SG decreases obesity and consequently increases expressions of MMP-3 and IL-6 genes. Conclusion: These data show alterations of MMP-3 and IL-6 genes in the substantia nigra tissue of obese rats, consistent with the possibility that these changes may contribute to disease molecular background.
