Review Article
The Role of Heated Intraperitoneal Chemotherapy (HIPEC) in Low-Grade Appendiceal Neoplasm: Friend or Foe?
Andrea Porpiglia, Duy Nguyen, Jeffrey Farma and Sanjay S Reddy*Fox Chase Cancer Center, Philadelphia, PA, USA
- *Corresponding Author:
- Sanjay S Reddy
Fox Chase Cancer Center, Philadelphia, PA, USA
Tel: 1 215-728-2570
E-mail: sanjay.reddy@fccc.edu
Received date: October 13, 2015; Accepted date: November 2, 2016; Published date: November 9, 2016
Citation: Porpiglia A, Nguyen D, Farma J, Reddy SS (2016) The Role of Heated Intraperitoneal Chemotherapy (HIPEC) in Low-Grade Appendiceal Neoplasm: Friend or Foe? J Gastrointest Dig Syst 6:477. doi: 10.4172/2161-069X.1000477
Copyright: © 2016 Porpiglia A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Low-grade mucinous appendiceal neoplasms are rare tumors. There is limited data on the treatment for pseudomyxoma peritonei with low-grade appendiceal histology. Classifications of appendiceal neoplasms include low-grade appendiceal mucinous neoplasm (LAMN), diffuse peritoneal adenomucinosis (DPAM), and peritoneal mucinous carcinomatosis (PMCA). Studies have demonstrated patients with low-grade appendiceal neoplasms have improved overall survival compared to patients with high-grade appendiceal neoplasms. Since low-grade tumors have better prognosis some retrospective trials have suggested observation in patients with these types of tumors. Another option includes cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC). We have done an extensive literature search exploring the various methods in which to treat patients with this disease.
