Journal of Child and Adolescent Behavior
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A hypothesis of series resonance in the white matter for understanding the mechanism of spike-wave seizures
Joint Event on 30th World Psychiatrists and Psychologists Meet and 3rd World Congress on Pediatric Neurology and Pediatric Surgery
Shigeki Sadahiro
Osaka Neurosurgical Hospital, Japan
Keynote: J Child Adolesc Behav
DOI:
Abstract
Background & Aim: Generalized epilepsy is accompanied by large-amplitude synchronized Spike-Wave Discharges (SWDs) on electroencephalography. Although some research groups continue to contend that both the thalamus and the cortex are involved in typical SWDs, the onset of SWDs is likely to vary. It remains unknown how most parts of the brain are synchronously and rapidly involved. To clarify this, a phenomenon is followed by hypothesizing a series resonance in an equivalent electric circuit for the white matter. This hypothesis is based on the ideas that the electric conduction along an axon is due to the displacement current and that the unit structure composed of a node of Ranvier and the next node can be regarded as a capacitor or an inductor, depending on the geometry and the substance around the nodes. Method: The flash-visual evoked potentials at various flash repetition rates were measured in patients with generalized epilepsy and compared with those for healthy controls and patients with focal epilepsy. Result: The P100 amplitude plotted against the flash repetition rate had a maximum peak at a certain flash repetition rate for each of the patients with generalized epilepsy, whereas there was no such peak for the controls or the patients with focal epilepsy. Conclusion: The observation of a peak in the P100 amplitude at a certain repetition rate was inferred to reflect the series resonance phenomenon in the white matter. Patients with generalized epilepsy have large regions of white matter with similar resonance frequencies.Biography
Shigeki Sadahiro has completed his studies in Physics from the University of Tokyo and joined Mitsubishi Electric as an Engineer helping to develop semiconductor technology. He is working as Neurologist at Osaka University Medical School. He has been working aggressively in the field of epilepsy for the last 10 years and has found it a challenge to understand how most parts of the brain are synchronously and rapidly involved in generalized epilepsy.
E-mail: estate0360@yahoo.co.jp
