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Alzheimer锟絪 disease (AD) is a progressive neurodegenerative disease with an unknown cause. Nevertheless, a number of
risk factors for AD has been identified, including ageing together with genetic andenvironmental factors. An important
modifiable life style factor that is associated with AD is diet. Many epidemiological studies have demonstrated that adherence to
diets rich in fish, fresh fruit and vegetables is associated with a lower risk of developing AD. In addition, studies show that plasma
levels of selected nutrients are reduced in AD; a finding that is confirmed by meta-analyses evenwith normal dietary intake and
in the absence of malnutrition. The impaired systemic availabilityof these nutrients may in part be explained by compromised
endogenous production, transport and transfer of nutrients over physiological barriers that evolve as a consequence of aging
or disease. In addition, there seems to be an increased utilization of nutrients for AD pathology-related processes, such as the
production of membrane phospholipids to stimulate synapse formation.Indeed, many of the nutrients with low plasma levels
in AD are involved in phospholipids synthesis; either as precursor or as co-factor. Based on these insights, the specific nutrient
combination Fortasyn-Connect (UMP, DHA, EPA, choline, phospholipids, folate, vitamins B6, B12, C, E, and selenium) was
designed for the dietary management of AD. When tested in patients with early AD we not only observed elevated plasma
nutrient levels, but also preserved functional brain connectivity and concomitant improvements in memory performance. Our
data indicate thataddressing the specific nutritional needs in early AD may offer potential in AD management.
Biography
Laus Broersen studied Psychopharmacology at Utrecht University and obtained his PhD at the age of 28 upon completion of his thesis on the prefrontal cortex at
the NIBR in Amsterdam.Since 2000 his research focuses on the relationship between nutrition and brain health, currently at Nutricia Research. He is interested in
nutritional concepts to support brain health and function in specific target populations. As such, he has been involved in the development of 锟絊ouvenaid锟�, a medical
nutrition formulation studied for potential use in the dietary management of early Alzheimer锟絪 disease. He has published more than 35 papers in peer-reviewed
journals.
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