Journal of Alzheimers Disease & Parkinsonism
黑料网
Our Group organises 3000+ Global Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ 黑料网 Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
黑料网 Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Citations : 4334
Indexed In
- Index Copernicus
- Google Scholar
- Sherpa Romeo
- Open J Gate
- Genamics JournalSeek
- Academic Keys
- JournalTOCs
- China National Knowledge Infrastructure (CNKI)
- Electronic Journals Library
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- SWB online catalog
- Virtual Library of Biology (vifabio)
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- ICMJE
Useful Links
Recommended Journals
Related Subjects
Share This Page
Cerebrovascular hemodynamics and vascular dementia
Yuhong Man, Gang Yao and Ping Xu
The Second Hospital of Jilin University, China
: J Alzheimers Dis Parkinsonism
Abstract
Statement of the Problem: Recent evidence suggests that vascular risk factors and neurovascular dysfunction may be related to dementia. This study was performed to evaluate the association between hemodynamic markers and the cognitive impairment in patients with Vascular Dementia (VaD).Method: A total of 65 VD participants were included. Using Transcranial Doppler (TCD) ultrasonography, Cerebrovascular Reactivity (CVR) was evaluated with the Mean blood Flow Velocity (MFV), Pulsatility Index (PI) and Resistance Index (RI) of the middle cerebral artery. Mini-Mental State Examination (MMSE) and magnetic resonance imaging of the brain was performed to evaluate cognitive impairment and cerebral small vessel disease. All patients were interviewed for 12 follow-up months.
Findings: Adjusting for covariates such as age, education, vascular risks, higher PI were observed in patients. The changes of MMSE score over 12 months were closely related to higher RI and PI values. Multivariate logistic regression showed that abnormal baseline PI value could predict a conversion from mild to severe of VaD (P<0.001).
Conclusion: Our findings may be suggestive of an underlying relationship between hemodynamic changes and VaD. There is a close association between hemodynamic markers represented by TCD and cognitive decline, supporting the clinical value of hemodynamic markers in predicting VaD patients from mild to severe.
Biography
Yuhong Man has her expertise in headache, cerebral disease and sleep disorders. Her research is in the basics and clinical of the acute and chronic headache, such as migraine and tension type headache. She also has 14 years’ experience in neurology about cerebral disease and sleep disorders, teaching and administration both in hospital and education institutions in Jilin University.
E-mail: myh1996@163.com
