International Journal of Emergency Mental Health and Human Resilience
黑料网
Our Group organises 3000+ Global Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ 黑料网 Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
黑料网 Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Citations : 4948
Indexed In
- Index Copernicus
- Google Scholar
- CiteFactor
- Publons
- Pubmed
- science Gate
- scispace
- world cat
Useful Links
Related Subjects
Share This Page
Docosahexaenoic acid prevents resistance to antiepileptic drugs in two animal models of drug-resistant epilepsy
29th International Conference on Public Mental Health and Neuroscience
Morteza Zendehde, Melika Moezifar, and Mohammad Sayyah
University of Tehran, Iran
ScientificTracks Abstracts: Int J Emerg Ment Health
DOI:
Abstract
Objectives: One-third of epileptic patients are resistant to antiepileptic drugs. Few clinical studies with small sample size indicate that polyunsaturated fatty acids could control drug-resistant epilepsy. We examined the efficacy of acute and chronic administration of docosahexaenoic acid (DHA) in two animal models of drug-resistant epilepsies, i.e. 6-Hz psychomotor seizures in mice and lamotrigine (LTG)- resistant kindled rats. Methods: Mice received a single injection of DHA (300 渭M, i.c.v.) along with phenytoin (PHT) or LTG (i.p.). Six-Hz electroshock (0.2 milliseconds rectangular pulse width, 3 seconds duration, 44 mA current) was given 15 minutes after DHA, and seizure behaviors were recorded. In LTG-resistant kindled rats, a single dose of DHA (300 渭M, i.c.v.) was administered with LTG, and seizure parameters were measured. In chronic treatment, mice received DHA (0.1 g/day, orally) for 30 days. Then, a single dose of LTG or PHT was administered to mice and 6-Hz-induced seizures were recorded. In rats, DHA (1 渭M, i.c.v.) was administered during kindling development and effect of LTG in DHA-pretreated LTG-resistant kindled rats was verified. Results: LTG and PHT did not inhibit 6-Hz seizures in mice after single injection of DHA. However, LTG and PHT inhibited 6-Hz seizures in mice that received DHA for 1 month. Acute or chronic administration of DHA to LTGresistant kindled rats led to the suppression of kindled seizure parameters by LTG. Discussion: DHA removes the 鈥榠nherent resistance鈥� of 6-Hz seizures to PHT and LTG, and prevents the development of pharmacodynamic tolerance to LTG in LTG-resistant kindled rats. DHA might have potential to be used as add-on therapy in patients with refractory epilepsy.Biography
Morteza zendehdel has completed his PhD at the age of 25 years from University of Tehran and postdoctoral studies from Monash University, School of Medicine. He is academic member of University of Tehran. He has published more than 40 papers in reputed journals and has been serving as an editorial board member of Neurotransmitter Journal.
E-mail: zendedel@ut.ac.ir
