ISSN: 2161-0460
Journal of Alzheimers Disease & Parkinsonism
黑料网
Our Group organises 3000+ Global Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ 黑料网 Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
黑料网 Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Citations : 4334
Indexed In
- Index Copernicus
- Google Scholar
- Sherpa Romeo
- Open J Gate
- Genamics JournalSeek
- Academic Keys
- JournalTOCs
- China National Knowledge Infrastructure (CNKI)
- Electronic Journals Library
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- SWB online catalog
- Virtual Library of Biology (vifabio)
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- ICMJE
Useful Links
Recommended Journals
Related Subjects
Share This Page
Gastro-intestinal symptoms in early stage parkinson’s disease
Joint Event on 5th World Congress on Parkinsons & Huntington Disease & 5th International Conference on Epilepsy & Treatment
Nehal Yemula
University of East Anglia, UK
Posters & Accepted Abstracts: J Alzheimers Dis Parkinsonism
Abstract
Background: In Parkinson鈥檚 disease, here is growing evidence that the initial pathophysiological changes occur in the gastrointestinal tract before changes are seen within the brain. We aim to investigate the prevalence of GIT symptoms in early-stages PD and the association between GIT symptoms and the UPDRS.Methods: 10 Early-Stage PD and 8 control patients were recruited from the Norfolk and Norwich University Hospital. UPDRS motor scores were completed at outpatient clinics with participants handed a PD-specific gastrointestinal questionnaire whereby both the severity and frequency was assessed. The symptoms assessed were abdominal pain, constipation, tenesmus, hard stools, reflux, dysphagia, early satiety and bloating.
Results: The frequency of symptoms within the PD group were tenesmus (80%), bloating (60%), reflux (60%), abdominal pain (50%), constipation (50%) and hard stools (50%), early satiety (20%) and dysphagia (10%). Tenesmus (p=0.02) was the only symptom to show a statistically significant difference between PD and control groups. The total median GIT symptoms score for PD and Control was 7.0 (IQR 2.0 to 9.0) and 1.0 (IQR 0.0 to 5.75), respectively with statistical signifcance (p=0.05). For total gastrointestinal and UPDRS motor scores, there was a positive correlation (r=0.239), although not significant (p=0.51).
Conclusions: Gastrointestinal symptoms were present in the majority of early-stage patients. Lower gastrointestinal symptoms were more prevalent that upper gastrointestinal symptoms which links in with Braak鈥檚 hypothesis. Further research into the timing of the symptoms in relation to diagnosis is cruicial and may lead to earlier diagnosis of PD.
