ISSN: 2161-0460
Journal of Alzheimers Disease & Parkinsonism
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Metabolic dysfunction underlying response of ketogenic diet in children with refractory epilepsy and potential diagnostic and treatment approaches
Joint Event on 5th World Congress on Parkinsons & Huntington Disease & 5th International Conference on Epilepsy & Treatment
Ahmed Mohamed Abdelhalim Mohamed Elsakka
Envision Foundation for Metabolic Research, Egypt
Posters & Accepted Abstracts: J Alzheimers Dis Parkinsonism
Abstract
Refractory epilepsy or drug-resistant epilepsy is defined as a failure of adequate trials of 2 tolerated and appropriately chosen and used AED schedules. 鈥淣euroscience Center, King Fahad Medical City 2011鈥�. The most effective line of treatment for refractory epilepsy is the ketogenic diet, however, about 20 to 30 % of the patient doesn鈥檛 respond to KD and continue to have seizures, despite adherent to ketosis.The aim of this study to define serum biomarkers that determined the efficacy of the ketogenic diet and to determine other metabolic cause contributing to epilepsy & should be managed first before KD implantation.Research Hypothesis: Many metabolic dysfunctions can contribute to seizure activity and had an impact on KD response, homeostasis, stress, defect in neuronal homeostasis, hyper ammonia, oxidative stress, cellular hypoxia, homocysteinemia and epigenetics, and DNA methylation defect all are contributing to epilepsy and must be excluded and managed before implantation of KD.
