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The main purpose of the study was to assess glycemic
control among statin users versus non-users in type 2
diabetes patients for a nine-year follow-up period.
Method: A retrospective cohort study was used on 204 study
subjects in Tikur Anbesa Specialized Hospital. Medical records
of eligible patients were followed from January 1, 2011
until the occurrence of the outcome, date of administrative
censoring or April 24, 2019. An assumption for proportional
hazard was met after testing through a graphical method
by log minus log curve and the time-dependent Cox-model.
A sensitively analysis and propensity score analysis was
also performed. In this propensity-matched cohort, Kaplan-
Meier analysis was repeated. An independent samples t-test
was used to compare the mean of the continuous variables
between the two cohorts. Moreover, incidence rates per 100
person-years were employed to crudely determine rates of
the poor glycemic control. Lastly, Cox regression analysis was
done to find out the effects of independent variables on the
outcome variables.
Result: The mean fasting blood glucose of statin users and
non-statin users were 176.2 mg/dL (standard error of mean
[SEM]: 2.9 mg/dL) and 163.9 (SEM: 3.1 mg/dL, respectively.
The Kaplan- Meier analysis showed that non-statin users
had a better glycemic control than patients who were taking
statins at all levels of time (Log Rank Chi-Square=19.1, p <
0.001). Besides this, after propensity score matching, there
was a statistically significant difference in mean FBG time
between statin users and non-statin users (t202 = 2.901,
p<0.004). Concerning the predictors, there were statistically
significant difference for glycemic control for ages ranging
50 to 54 years (adjusted hazard ratio [AHR] =0.401; 95% CI
[confidence interval]: 0.195芒�?�?0.823), metformin 1000 mg
(AHR=0.410; 95% CI: 0.243芒�?�?0.693) and simvastatin 40 mg
(AHR=0.396; 95% CI:
0.229芒�?�?0.686) compared to their corresponding controls (75
to 79 years and the absence of the medications,respectively
Conclusion: This study provides a benchmark for assessing
the association of statins with poor glycemic control at the
comprehensive specialized hospital. Moving forward, we call
for the health care providers to closely monitor the glycemic
control of diabetic patients taking statins and place a special
effort in optimizing the treatment outcome.
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