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Abstract

Clostridium difficile infections (CDIs) had become the major burden on the healthcare system. These infections are the result of collateral damage to the normal bacterial flora of the human body, which is an inevitable complication of antibiotics use. CDIs pose an immediate threat to the health of patients received antibiotics, more so than antimicrobial resistance. Considering CDIs are nearly always complications of antibiotics use, the development of the program to ensure appropriate antibiotics use is considered an important prevention intervention. The multidisciplinary managed program such as antimicrobial stewardship has been initiated in healthcare facilities to control the misuse of antimicrobial therapies and reduce their complications. Clinical pharmacist involved antimicrobial ward-round is designed to help limit CDIs and other hospital-associated organisms by optimizing antimicrobial selection, dosing, de-escalation, and duration of antimicrobial therapy. Other activates such as audit with feedback and antibiotic restriction also have been established to impact on the antimicrobial utilization. These programs also incorporate the implementation of hospital-wide guidelines, staff education, enforcement of infection-control policies, and the use of electronic medical records when possible to help control antimicrobial use. The literature strongly emphasizes how antimicrobial stewardship programs impact on CDIs rates discusses experiences in designing, implementing, monitoring, and follow-through of such programs. Literature shows the significant decrease in the use of parenteral broadspectrum antibiotic and in the incidence of CDI.

Biography

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