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The promising rule of neutrophil cd64 as an early diagnostic and prognostic marker in neonatal sepsis
World Congress on Infectious Diseases
Shereen Ahmed El Masry1, Heba EzzatHashem1, Nour EL Din M. Abdel Aal2, Amira Mohammed Mokhtar1 and Zahra Madentnaser
ScientificTracks Abstracts: J Infect Dis Ther
DOI:
Abstract
Background: In spite of extensive research for understanding and treatment of neonatal sepsis, sepsis stills a major source of
morbidity and mortality among neonates, it represents a diagnostic burden problem by showing minimal initial nonspecific
manifestations. The clinical course can be fulminate and fatal if treatment is not commenced promptly. Neutrophil CD64
showing a promising value as early diagnostic and prognostic marker for neonatal sepsis.
Aims: Our aim was to assess nCD64 as an early predictive and monitoring marker and the best panel of markers that can
achieve the highest diagnostic performance in this disease.
Methods: This study conducted over 8-months and included a total of 175 sepsis evaluations, neonates classified into three
groups: Documented sepsis group, Clinical sepsis group and Control group. Blood samples were collected for hs-CRP, CBC,
nCD64 (done by Flow Cytometry) and blood culture to confirm the diagnosis in the patient’s group.
Results: A significant increase in nCD64 was found in sepsis group than in control group. nCD64 had AUC = 0.864 with an
optimal cut off at 42% with sensitivity of 86 %, specificity 93.3%, NPV 68.3 %, PPV 97.5 % and efficacy 87.7%. Combination of
CRP and CD64 achieve the highest diagnostic and prognostic performance over the other haematological parameters.
Conclusions: We can conclude that nCD64% & CRP combination represent the best early predictor and monitoring panel of
markers that can be used conventionally in NICU, Our study suggests that nCD64 % is ready to be incorporated in the routine
daily work as a valuable marker.
