黑料网

Abstract

The microRNA (miRNA) is small, non-encoding RNA and plays important role in various biological conditions by regulating the expression of target gene at the post-transcriptional level. miRNAs are involved in the normal functioning of eukaryotic cells, and dysregulation of miRNA been associated with various diseases including inherited disorders, cancer, cardiomyopathy, and obesity. The expression profile of miRNA is specific for the tissue, indicating a potential value of miRNAs as a biomarker for disease diagnosis and prognosis. Research about miRNAs in veterinary medicine is in infant stage. Especially, no baseline laboratory data about equine miRNAs are available. In the present study, global profile of equine miRNAs was investigated in blood and several tissues by Next Generation Sequencing (NGS) technology. A total of 306 known miRNAs that reported in miRbase were identified and 95 miRNAs were commonly found in different organs including muscle, colon and liver. Distinct set of tissue miRNAs were also present in the serum. The present study revealed lists of miRNAs expressed in the major organs, suggesting that blood miRNAs could be utilized as a biomarker for tissue damage. The present study provides valuable background information for further studies about the development of diagnostic tool for equine diseases.

Biography

Yongbaek Kim has completed combined program of Ph.D. and resident training of veterinary anatomic pathology from The University of Georgia and postdoctoral studies from National Institute of Environmental Health Sciences. He is the board certified veterinary pathologist and serving as an Associate Director of Veterinary Medical Teaching Hospital of College of Veterinary Medicine, Seoul National University. He has published more than 40 papers in reputed journals and has been serving as an editorial board member of multiple journals.