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Abstract

Low-grade endometrial stromal sarcomas constitute the majority of endometrial stromal neoplasms; they frequently contain chromosomal rearrangements that result in JAZF1-SUZ12 fusion or other equivalent genetic fusions. The tumors that have variably been referred to as �??high-grade endometrial stromal sarcomas�?� are more uncommon and are more clinically aggressive than their low grade counterparts. The new WHO 2014 classification essentially defined the latter by the presence of YWHAE-NUTM2A/B (YWHAE-FAM22A/B) fusions. Overall, the diagnostic approach to high grade endometrial stromal sarcomas by pathologists has undergone a significant evolution in the past several decades. In this presentation, this historical evolution is reviewed in detail, with a description of current diagnostic criteria, limitations of current classification schemes and a proposal that incorporates all currently available data.

Biography