Journal of Clinical & Experimental Pathology
黑料网
Our Group organises 3000+ Global Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ 黑料网 Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
黑料网 Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Citations : 2975
Indexed In
- Index Copernicus
- Google Scholar
- Sherpa Romeo
- Open J Gate
- Genamics JournalSeek
- JournalTOCs
- Cosmos IF
- Ulrich's Periodicals Directory
- RefSeek
- Directory of Research Journal Indexing (DRJI)
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- ICMJE
- world cat
- journal seek genamics
- j-gate
- esji (eurasian scientific journal index)
Useful Links
Recommended Journals
Related Subjects
Share This Page
Impact of CYP3A5 and MDR1 gene polymorphisms on the dose and level of tacrolimus among living related liver transplanted patients
7th World Congress on Molecular Pathology
Manal Kamal
Cairo University, Egypt
ScientificTracks Abstracts: J Clin Exp Pathol
DOI:
Abstract
Aim: To assess the impact of Cytochrome P450 3A5 (CYP3A5) and multidrug resistance-1 gene (MDR-1) single nucleotide polymorphisms on the dose and blood level of tacrolimus among liver transplanted patients. Patients & Methods: We enrolled a prospective study of 41 liver transplanted patients. Dose adjusted through blood concentration (C/D ratio) was calculated. Polymerase chain reaction restriction fragment length polymorphism followed by sequencing was done for genotyping of CYP3A5*3 (6986A4G). Results: At 1 week, 1 and 3 months C/D ratio were significantly lower in CYP3A5 expressers *1/*1 patients compared to nonexpressers *3/*3. Conclusion: CYP3A5 (6986A4G) genotype, rather than MDR-1 (2677G4A/T) variant has an impact on tacrolimus pharmacokinetics.Biography
Manal Kamal is an academic person from the Department of Clinical and Chemical Pathology at Cairo University, Egypt. His research interest includes Molecular Pathology, Clinical and Molecular Genetics.
Email: manalmk@yahoo.com
