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Impact of moderate intensity aerobic exercise on chemotherapy-induced anemia in elderly women with breast cancer: A randomized controlled clinical trial
Exercises are often recommended for patients suffering from anemia to improve physical conditioning and hematologic
parameters. Hence, the present study aimed to investigate the impact of moderate intensity aerobic exercise on
chemotherapy-induced anemia. 30 elderly women with breast cancer underwent chemotherapy and were randomly assigned
into two equal groups, Group A received aerobic exercise for 25-40 minutes at 50-70% of the maximum heart rate, 3 times/
week for 12 weeks in addition to usual daily living activities, medication and nutritional support. Group B who did not train
served as controls. Hemoglobin (Hb), and red blood cell count (RBCs) were evaluated pre-treatment and after 12 weeks of
training. There were significant declines of both Hb (t=16.30; P<0.001) and RBCs (t=10.38; P<0.001) in group B relative to
group A. Regarding group A, Hb increased from 11.52�±0.62 to 12.10�±0.59 g/dL with a 5.03% change, while RBCs increased
from 4.24�±0.37 to 4.49�±0.42 million cells/�¼L with a 5.89% change. Between-group differences were noteworthy regarding Hb
(t=-5.34; P<0.001) and RBCs (t=-5.314; P<0.001). The results indicate that regular participation in moderate intensity aerobic
exercise can enhance chemotherapy-induced anemia.