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Gene-based molecular diagnostics is changing the practice of medicine and will continue to do so for the
foreseeable future. The major underlying principle of these diagnostic tests is the use of specific nucleic acid
sequences as surrogates; amplification of the surrogate markers enables the detection of pathogens or disease-
related gene mutations. Gene targets can be amplified by target-, probe or signal-based methods. Molecular
profiling of various diseases using genomic or proteomic approaches opens up a molecular wonderland with
promise and emergence of new molecular testing that will impact the practice of medicine to a greater degree in
the future. My lecture will cover the followings:
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Definition of individualized molecular testing and personalized medicine
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Paradigm change of current medicine to personalized medicine
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Review of commercially available individualized molecular-based testing
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Definition and examples of theragnostics
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Refined definition and examples of pharmacogenomics
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Definition and examples of prognomics
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Future perspectives on individualized molecular testing for personalized medicine
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Attend this lecture, you will:
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Understand the basic differences between the current medicine and personalized medicine
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Have an overall understanding of individualized molecular testing used in personalized disease treatments
and patient care
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Know the three subcategories of individualized molecular testing
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Apprehend the trend of future personalized healthcare
Biography
Richard Y. Zhao is a Professor of Pathology, Microbiology-Immunology and Human Virology at the School of Medicine, University of
Maryland Baltimore. He is also the Division Head of Molecular Pathology in the Department of Pathology, Director of Translational
Genomics Laboratory in the School of Medicine, and Director of Molecular Diagnostics Laboratory at the University of Maryland
Medical Center. His clinical expertise is in the area of molecular pathology and personalized medicine. His basic science research
interests are in HIV/AIDS, cancer biology and nanoparticle-based single molecule detections. He has published over one hundred
scientific papers and has served on numerous scientific editorial boards including Clinical and Applied Immunology Reviews,
Clinical Laboratory Science, Cell Research, Cell and Biosciences, Chinese Journal of Clinical and Experimental Virology, Journal
of Clinical and Experimental Pathology, Journal of Molecular Genetics, Frontiers in Virology, PLoS One and Retrovirology. He has
been invited to review scientific grant applications for funding agencies of nine different countries and has chaired a number of
NIH grant review study panels. He has been invited to give scientific lectures world-wide.
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