Journal of Clinical & Experimental Pathology
黑料网
Our Group organises 3000+ Global Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ 黑料网 Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
黑料网 Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Citations : 1437
Indexed In
- Index Copernicus
- Google Scholar
- Sherpa Romeo
- Open J Gate
- Genamics JournalSeek
- JournalTOCs
- Cosmos IF
- Ulrich's Periodicals Directory
- RefSeek
- Directory of Research Journal Indexing (DRJI)
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- ICMJE
- world cat
- journal seek genamics
- j-gate
- esji (eurasian scientific journal index)
Useful Links
Recommended Journals
Related Subjects
Share This Page
Survivin and caspase-3 as diagnostic and predictive biomarkers of recurrence for urinary bladder carcinoma after transurethral resection of bladder tumor
Joint Event on 15th International Congress on American Pathology and Oncology Research & International Conference on Microbial Genetics and Molecular Microbiology
Vivian GD Rouston, Amal AA Shaaban, Dina M Abd Allah and Ahmed F Kotb
Ministry of Health, EgyptUniversity of Alexandria, Egypt
Posters & Accepted Abstracts: J Clin Exp Pathol
DOI:
Abstract
Background: Bladder cancer even in early stage develop recurrence. Poor sensitivity of cytology and invasiveness of urethrocystoscopy have generated interest in non-invasive tools to monitor for recurrence. Caspase-3 and survivin have a central role in the regulation of apoptosis. Survivin can aid early diagnosis, determine prognosis in multiple cancer types and predict response to anti-cancer therapies. Its combination with other biomarkers as caspase-3 enhance prognostication and prediction of treatment response in Urinary Bladder Cancer or Carcinoma (UBC). Methods: Immunohistochemical expression of survivin and caspase-3 were assessed in 44 Egyptian consecutive patients with UBC and 7 cystoscopic biopsies of cystitis as control reactive benign urothelium. Relationships between their expression, clinicopathological characteristics, diagnostic and prognostic performance were statistically analyzed. Findings: No survivin immunoreactivity was identified in non-neoplastic bladder tissue. Expression of survivin and caspase-3 was altered in 42(95.5%) and 10(22.7%) cases, respectively. There was a statistically significant moderate positive correlation between survivin and caspase-3 expression among whole studied cases (p=.006). Expression of either survivin or caspase-3 protein individually significantly differ (p=0.000) in cancer status from control cases. Survivin was an independent predictor of UBC in multivariable analyses. Diagnostic accuracy of survivin alone was significantly better than caspase-3 alone (sensitivity 81.82% vs 68.18%, p=.027). Addition of survivin immunoreactivity to a model including caspase-3 expression improved diagnostic accuracy with a sensitivity of 93.18%. Addition of gender to the previous model improved more diagnostic accuracy with a sensitivity of 100%. Interpretation: Survivin alone is a very promising marker and reliable indicator in UBC. Survivin and caspase-3 antigens have a cooperative effect on bladder cancer, their simultaneous evaluation augments diagnostic sensitivity.Biography
Vivian GD Rouston was born in 1979. She obtained her MBBCh in 2004 and Master of Anatomic Pathology in 2015 from Faculty of Medicine Alexandria University. She was trained for histopathology and cytopathology at histopathology division of the Department of Pathology, St James's university hospital, the Leeds Teaching Hospitals, NHS Trust, United Kingdom. She is working as a histopathology specialist in a general hospital of the Egyptian Ministry of Health.
E-mail: v_dabous@hotmail.com
