Journal of Clinical & Experimental Pathology
黑料网
Our Group organises 3000+ Global Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ 黑料网 Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
黑料网 Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Citations : 2975
Indexed In
- Index Copernicus
- Google Scholar
- Sherpa Romeo
- Open J Gate
- Genamics JournalSeek
- JournalTOCs
- Cosmos IF
- Ulrich's Periodicals Directory
- RefSeek
- Directory of Research Journal Indexing (DRJI)
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- ICMJE
- world cat
- journal seek genamics
- j-gate
- esji (eurasian scientific journal index)
Useful Links
Recommended Journals
Related Subjects
Share This Page
Using Computer Aided Drug Design and docking softwares to determine In-Silico Metformin Binding site with its receptor AMP Kinase Enzym
Joint Event on 6th World Congress and Expo on Breast Pathology and Cancer Diagnosis & 20th International Conference on Medicinal Chemistry and Rational Drugs
Farah Yousef
Damascus University, Syria
ScientificTracks Abstracts: J Clin Exp Pathol
DOI:
Abstract
Metformin receptor has been studied for decades as this drug is one of the most popular drugs used in the treatment of Type II diabetes Mellitus (TIIDM) in the globe. Different studies have confirmed that its receptor is AMPKinase enzyme in the liver cells. But, no crystal structure was found yet for its binding to the proposed enzyme. What we tried here is to use our experiences in medicinal Chemistry and Computer Aided Drug Design in a try to study Metformin binding site with AMPKinase in silico using two docking softwares and one internet site. AMPKinase crystal structure was downloaded from Protein Data Bank database, while Metformin structure was got from Pubchem database. After analyzing the structures and the docking results we had, we came to a conclusion that agrees with recent biological studies about this investigation. We hope these results help researchers in drug design field to discover and\or developing new agents for the treatment of TIIDM considering Metformin as a lead compound for that.Biography
Farah Yousef is a PhD student from Damascus University. She has finished her previous studies at Faculty of Pharmacy at Tishreen University, Syria. She has published 6 articles so far in reputed journals and many Arabic articles in Arabic websites and has been serving as an editorial board member of repute in different journals. She has participated in different Syrian and Global conferences so far.
E-mail: farahyousef90@yahoo.com
